Journal Articles by E. Lau


S. Veitch, M. S. Njock, M. Chandy, M. A. Siraj, L. Chi, H. Mak, K. Yu, K. Rathnakumar, et al.
MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes
Cardiovasc Diabetol, 21(1), 31, 2022
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R. Ludwig and E. Lau
JCAST: Sample-specific protein isoform databases for mass spectrometry-based proteomics experiments
Software Impacts, 10, 100163, 2021
proteomics mass spectrometry rna sequencing alternative splicing protein isoforms proteoforms proteogenomics
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Y. Han, L. Z. Li, N. L. Kastury, C. T. Thomas, M. P. Y. Lam, and E. Lau
Transcriptome features of striated muscle aging and predictability of protein level changes
Mol. Omics, 2021
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K. C. Woulfe, D. A. Jeffrey, J. P. D. Silva, C. E. Wilson, J. H. Mahaffey, E. Lau, D. Slavov, F. Hailu, et al.
Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake
J Mol Cell Cardiol, 159, 28-37, 2021
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T. Chour, L. Tian, E. Lau, D. Thomas, I. Itzhaki, O. Malak, J. Z. Zhang, X. Qin, et al.
Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies
JCI Insight, 6(7), 2021
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Y. Han, S. D. Wood, J. M. Wright, V. Dostal, E. Lau, and M. P. Y. Lam
Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart
J Mol Cell Cardiol, 154, 92-96, 2021
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M. Chandy, J. W. Rhee, M. O. Ozen, D. R. Williams, L. Pepic, C. Liu, H. Zhang, J. Malisa, et al.
Atlas of exosomal microRNAs secreted from human iPSC-derived cardiac cell types
Circulation, 142(18), 1794-1796, 2020
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V. Dostal, S. D. Wood, C. T. Thomas, Y. Han, E. Lau, and M. P. Y. Lam
Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart
Sci Rep, 10(1), 18440, 2020
RIS, BibTex
J. X. Zhang, E. Lau, D. T. Paik, Y. Zhuge, and J. C. Wu
High-throughput preparation of DNA, RNA, and protein from cryopreserved human iPSCs for multi-omics analysis
Current protocols in stem cell biology, 54(1), e114, 2020
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J.-W. Rhee, H. Yi, D. Thomas, C. K. Lam, N. Belbachir, L. Tian, X. Qin, J. Malisa, et al.
Modeling secondary iron overload cardiomyopathy with human induced pluripotent stem cell-derived cardiomyocytes
Cell reports, 32(2), 107886, 2020
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E. Lau, Y. Han, D. R. Williams, C. T. Thomas, R. Shrestha, J. C. Wu, and M. P. Y. Lam
Splice-junction-based mapping of alternative isoforms in the human proteome
Cell reports, 29(11), 3751—3765.e5, 2019
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J. Lee, V. Termglinchan, S. Diecke, I. Itzhaki, C. K. Lam, P. Garg, E. Lau, M. Greenhaw, et al.
Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy
Nature, 572(7769), 335—340, 2019
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T. Seeger, R. Shrestha, C. K. Lam, C. Chen, W. L. McKeithan, E. Lau, A. Wnorowski, G. McMullen, et al.
A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay
Circulation, 139(6), 799—811, 2019
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E. Lau, D. T. Paik, and J. C. Wu
Systems-Wide Approaches in Induced Pluripotent Stem Cell Models
Annual review of pathology, 14, 395—419, 2019
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E. Lau, V. Venkatraman, C. T. Thomas, J. C. Wu, J. E. V. Eyk, and M. P. Y. Lam
Identifying high-priority proteins across the human diseasome using semantic similarity
Journal of proteome research, 17(12), 4267—4278, 2018
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E. Lau and J. C. Wu
Omics, big data, and precision medicine in cardiovascular sciences
Circulation research, 122(9), 1165—1168, 2018
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A. S. Lee, M. Inayathullah, M. A. Lijkwan, X. Zhao, W. Sun, S. Park, W. X. Hong, M. B. Parekh, et al.
Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix
Nature biomedical engineering, 2(2), 104—113, 2018
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F. Olmeta-Schult, L. M. Segal, S. Tyner, T. A. Moon, R. D.-W. Chow, P. Chakrabarty, M. Pacesa, A. I. Podgornaia, et al.
NextGen VOICES: Research resolutions
Science (New York, N.Y.), 359(6371), 26—28, 2018
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E. Lau, Q. Cao, M. P. Y. Lam, J. Wang, D. C. M. Ng, B. J. Bleakley, J. M. Lee, D. A. Liem, et al.
Integrated Omics Dissection of Proteome Dynamics During Cardiac Remodeling
Nature communications, 9(1), 120, 2018
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M. P. Y. Lam, E. Lau, D. C. M. Ng, D. Wang, and P. Ping
Cardiovascular proteomics in the era of big data: experimental and computational advances
Clinical proteomics, 13, 23, 2016
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M. P. Y. Lam, V. Venkatraman, Y. Xing, E. Lau, Q. Cao, D. C. M. Ng, A. I. Su, J. Ge, et al.
Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems
Journal of proteome research, 15(11), 4126—4134, 2016
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E. Lau, K. E. Watson, and P. Ping
Connecting the Dots: From Big Data to Healthy Heart
Circulation, 134(5), 362—364, 2016
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A. Gramolini, E. Lau, and P. P. Liu
Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases
Circulation, 134(4), 286—289, 2016
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E. Lau, Q. Cao, D. C. M. Ng, B. J. Bleakley, T. U. Dincer, B. M. Bot, D. Wang, D. A. Liem, et al.
A large dataset of protein dynamics in the mammalian heart proteome
Scientific data, 3, 160015, 2016
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M. Kudelko, C. W. L. Chan, R. Sharma, Q. Yao, E. Lau, I. K. Chu, K. S. E. Cheah, J. A. Tanner, et al.
Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress
Journal of proteome research, 15(1), 86—99, 2016
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M. P. Y. Lam, V. Venkatraman, Q. Cao, D. Wang, T. U. Dincer, E. Lau, A. I. Su, Y. Xing, et al.
Prioritizing Proteomics Assay Development for Clinical Translation
Journal of the American College of Cardiology, 66(2), 202—204, 2015
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E. Lau, D. Huang, Q. Cao, T. U. Dincer, C. M. Black, A. J. Lin, J. M. Lee, D. Wang, et al.
Spatial and temporal dynamics of the cardiac mitochondrial proteome
Expert review of proteomics, 12(2), 133—146, 2015
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X. C. Y. Chan, C. M. Black, A. J. Lin, P. Ping, and E. Lau
Mitochondrial protein turnover: methods to measure turnover rates on a large scale
Journal of molecular and cellular cardiology, 78, 54—61, 2015
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D. Wang, D. A. Liem, E. Lau, D. C. M. Ng, B. J. Bleakley, M. Cadeiras, M. C. Deng, M. P. Y. Lam, et al.
Characterization of human plasma proteome dynamics using deuterium oxide
Proteomics. Clinical applications, 8(78), 610—619, 2014
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N. Zong, P. Ping, E. Lau, H. J. Choi, D. C. Ng, D. Meyer, C. Fang, H. Li, et al.
Lysine ubiquitination and acetylation of human cardiac 20S proteasomes
Proteomics. Clinical applications, 8(78), 590—594, 2014
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M. P. Y. Lam, D. Wang, E. Lau, D. A. Liem, A. K. Kim, D. C. M. Ng, X. Liang, B. J. Bleakley, et al.
Protein kinetic signatures of the remodeling heart following isoproterenol stimulation
The Journal of clinical investigation, 124(4), 1734—1744, 2014
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C. Lotz, A. J. Lin, C. M. Black, J. Zhang, E. Lau, N. Deng, Y. Wang, N. C. Zong, et al.
Characterization, design, and function of the mitochondrial proteome: from organs to organisms
Journal of proteome research, 13(2), 433—446, 2014
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M. P. Y. Lam, E. Lau, D. A. Liem, and P. Ping
Cyclophilin D and acetylation: a new link in cardiac signaling
Circulation research, 113(12), 1268—1269, 2013
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L. J. Martin, E. Lau, H. Singh, L. Vergnes, E. J. Tarling, M. Mehrabian, I. Mungrue, S. Xiao, et al.
Response to Pomozi et al's research commentary
Circulation research, 112(11), e152—3, 2013
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M. P. Y. Lam, E. Lau, S. B. Scruggs, D. Wang, T.-Y. Kim, D. A. Liem, J. Zhang, C. M. Ryan, et al.
Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation
Journal of proteomics, 81, 15—23, 2013
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T.-Y. Kim, D. Wang, A. K. Kim, E. Lau, A. J. Lin, D. A. Liem, J. Zhang, N. C. Zong, et al.
Metabolic labeling reveals proteome dynamics of mouse mitochondria
Molecular & cellular proteomics : MCP, 11(12), 1586—1594, 2012
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M. P. Y. Lam, S. B. Scruggs, T.-Y. Kim, C. Zong, E. Lau, D. Wang, C. M. Ryan, K. F. Faull, et al.
An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue
Journal of proteomics, 75(15), 4602—4609, 2012
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L. J. Martin, E. Lau, H. Singh, L. Vergnes, E. J. Tarling, M. Mehrabian, I. Mungrue, S. Xiao, et al.
ABCC6 localizes to the mitochondria-associated membrane
Circulation research, 111(5), 516—520, 2012
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J. Zhang, A. Lin, J. Powers, M. P. Lam, C. Lotz, D. Liem, E. Lau, D. Wang, et al.
Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation
The Journal of general physiology, 139(6), 395—406, 2012
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E. Lau, D. Wang, J. Zhang, H. Yu, M. P. Y. Lam, X. Liang, N. Zong, T.-Y. Kim, et al.
Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria
Circulation research, 110(9), 1174—1178, 2012
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M. P. Y. Lam, E. Lau, S. Siu, D. C. M. Ng, R. P. W. Kong, P. C. N. Chiu, W. S. B. Yeung, C. Lo, et al.
Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples
Electrophoresis, 32(21), 2930—2940, 2011
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S. Siu, M. P. Y. Lam, E. Lau, R. P. W. Kong, S. M. Y. Lee, and I. K. Chu
Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics
Proteomics, 11(11), 2308—2319, 2011
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E. Lau, M. P. Y. Lam, S. Siu, R. P. W. Kong, W. L. Chan, Z. Zhou, J. Huang, C. Lo, et al.
Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications
Molecular bioSystems, 7(5), 1399—1408, 2011
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M. P. Y. Lam, S. Siu, E. Lau, X. Mao, H. Sun, P. C. N. Chiu, W. S. B. Yeung, D. M. Cox, et al.
Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization
Analytical and bioanalytical chemistry, 398(2), 791—804, 2010
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H. Liu, E. Lau, M. P. Y. Lam, H. Chu, S. Li, G. Huang, P. Guo, J. Wang, et al.
OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast function
The New phytologist, 187(1), 83—105, 2010
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S. Siu, M. P. Y. Lam, E. Lau, W. S. B. Yeung, D. M. Cox, and I. K. Chu
N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry
Methods in molecular biology (Clifton, N.J.), 600, 133—143, 2009
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Preprint


V. Dostal, S. Wood, C. Thomas, Y. Han, E. Lau, and M. P. Lam
Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart
bioRxiv, 2020
URL, DOI, RIS, BibTex
E. Lau, V. Venkatraman, C. Thomas, J. V. Eyk, and M. P. Lam
Identifying high-priority proteins across the human diseasome using semantic similarity
bioRxiv, 2018
URL, DOI, RIS, BibTex